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Toll like receptor ( TLRs) is a highly conserved transmembrane protein expressed in epithelial cells and immune cells,which is a kind of important receptor to identify the damage associated molecular patterns (DAMPs). TLRs and DAMP produced by tumor cells after chemotherapy combine to produce the corresponding biological effects via MyD88 dependent and independent path-ways. At present,the research application of TLRs identifying DAMP clinically is mainly focused on promoting the release of the DAMP and enhancing the expression of TLRs to strengthen the immune effect of chemotherapy drugs.
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Objective:To evaluate the clinical efficacy and safety of caffeic acid for thrombocytopenia induced by cancer chemothera-py. Methods:A total of 60 patients received the same chemotherapy treatment on cycles 1, 2, and 3. They were given mimetic agent as negative control on the first course. On the second and third cycles, caffeic acid tablets were given from the first day of chemothera-py. Results:The lowest and highest platelet levels of the treatment group during the drug treatment period were significantly higher than those of the negative control group (P<0.001). No significant difference in the period of days of PLT<50×109/L was observed be-tween the groups, although a decreasing trend (P>0.05) was observed. After chemotherapy, the days required for platelet recovery to PLT≥75×109/L and PLT≥100×109/L in the treatment group was significantly fewer than in the negative control group (P<0.001). All the patients did not receive any platelet transfusion during the trial. Conclusion:Caffeic acid tablets were safe and effective for thrombocy-topenia induced by tumor chemotherapy.
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Objective:To evaluate the clinical efficacy and safety of caffeic acid for thrombocytopenia induced by cancer chemothera-py. Methods:A total of 60 patients received the same chemotherapy treatment on cycles 1, 2, and 3. They were given mimetic agent as negative control on the first course. On the second and third cycles, caffeic acid tablets were given from the first day of chemothera-py. Results:The lowest and highest platelet levels of the treatment group during the drug treatment period were significantly higher than those of the negative control group (P<0.001). No significant difference in the period of days of PLT<50×109/L was observed be-tween the groups, although a decreasing trend (P>0.05) was observed. After chemotherapy, the days required for platelet recovery to PLT≥75×109/L and PLT≥100×109/L in the treatment group was significantly fewer than in the negative control group (P<0.001). All the patients did not receive any platelet transfusion during the trial. Conclusion:Caffeic acid tablets were safe and effective for thrombocy-topenia induced by tumor chemotherapy.
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Objective To discuss the efficiency and safety of thalidomide combined with mFOLFOX in trea-ting advanced colon cancer.In addition,to observe the influence of mFOLFOX combined with thalidomide on serum vascular endothelial growth factor(VEGF)leveles.Methods One hundred patients with advanced colon cancer were divided randomly into two groups by digital table method.In the combined group,fifty patients were treated by mFOL-FOX combined with thalidomide.In the control group,fifty patients were treated by mFOLFOX alone.All the patients were tested serum VEGF before and after four cycle of chemotherapy.Results The response rate was 42% in the combined group vs.38% in the control group.Higher clinical benefit rate was found in the combined group (78% vs. 68%).The median time to progression(TTP)was 110 days vs.107 days.The differents between the two groups were not statistically significant(all P >0.05).After treatment of 4 cycles,the serum VEGF concentration of combined group and control group were respectively(317.40 ±55.54)ng/L and (330.84 ±64.48)ng/L,which were signifi-cantly decreased compared with pretreafment.The combination group decreased more obviously,the difference between the two groups were statistical significance(t =11.634,P =0.000).Conclusion Combined thalidomide with mFOL-FOX can′t improved clinical curative effect on the advanced colon cancer significantly.However,thalidomide can re-duce the levels of serum VEGF,and improve the quality of life.
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Objective To discuss the clinical efficacy of advanced primary liver cancer under the chemother-apy of hyperthermia combined with EOF approach.Methods 75 patient samples who had advanced primary liver cancer in total were chosen and were divided into the two groups randomly.The control group containing 37 patient samples had advanced primary liver cancer which would be applied with EOF approach.The treatment group contai-ning 38 samples had advanced primary liver cancer.The treatment strategy was to apply EOF approach combined with high -frequency hyperthermia in vitro.Results The total rate of efficiency on the treatment group and control group was 73.68% vs 48.6%.The DCR rate was 92.1% versus 56.8%,1 year survival rate was 57.8% versus 45.9%and 2 years survival rate was 10.5% versus 5.4% which showed that the results of the treatment group was obviously better than that of the control group.Conclusion The method that combining the chemotherapy of hyperthermia with EOF to treat advanced primary liver cancer can obviously improve clinical efficacy and survival period.What′s better is that this approach will not increase the toxicity of chemotherapy.
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Objective To confirm the deviation between the present charge and real cost of nursing by comparing them between PICC and jugular veins catheter,and the advantages and disadvantages were weighed between them in tumor patients undergoing chemotherapy.Methods The cost of manpower,financial resources or materials for 106 patients with PICC,68 patients with jugular veins catheter were measured,accounted and statistically analyzed with the ladder sharing method for project cost.Comparing the cost between calculation cost and current charging standard,and the cost and clinical application was studied.Results The real cost of PICC was (2259.99±30.99)Yuan and current charging standard was 1532.79 Yuan,the deviation was -727.20 Yuan,and the real cost of jugular veins catheter was (393.86±33.93) Yuan,and current charging standard was 292.13 Yuan,the deviation was -101.73 Yuan.The complication rate was 12％ in PICC,17％ in jugular veins catheter.The real cost of nursing on PICC and jugular veins catheter was higher than current charging standard,and the real cost of single nursing on PICC was 5.74 times higher than jugular veins catheter.The cost remains unchanged with 4～6 course of chemotherapy treatments in a year.Conclusions The advantages of PICC are more than jugular veins catheter,so the preferred choice is PICC,and jugular veins catheter comes secondary.
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0.05),and NK cells function(CD56),humoral immunologic function(IgG,IgM,IgA)were significantly elevated after TP-5 administration for 3 months(Pa
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Multi-drug resistance(MDR) is the most frequent reason for tumor chemotherapeutic failure.ATP binding cassette(ABC) drug transporters play an important role in tumor MDR.ABCC1 is one of the members of ABC transporter super-family,which lead to drug risistance via discarding drug out of cell or changing the drug distribution in a cell.In this article,we reviewed the advance in MDR mediated by ABCC1 and its reverse.
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OBJECTIVE:To observe the synergism and attenuation of Fermented Radix Astragali Powder(FAP)on Cyc-lophosphamide(Cy),a tumor chemotherapeutics,and to explore more economical and effective assistant chemotherapeutics.METHODS:In synergism experiments,the mice tumor models(S180 and H22 solid tumor and H22 ascitic tumor)were used to observe the effects of FAP combined with Cy on tumor control rate and survival time of mice.In attenuation experiments,the effects of FAP against toxic reactions including myelosuppression,atrophy of immune organs,and lesions on renal function induced by high dose of Cy in mice were observed.RESULTS:FAP did enhanced the the antitumor effect of Cy on S180 and H22 solid tumor,lessened Cy-induced toxic reactions such as aleucocytosis,the reduction of the nucleated cells in bone marrow and the weight loss of spleen in mice,meanwhile,it showed protective effect on renal function yet without no significant influence on hepatic function.CONCLUSION:FAP has synergistic and attenuation effects on Cy.